60 Billion Oops

What's a little Somatic Hyper Mutation-targeting element amongst friends?

An X follower pointed me to this PrePrint.

What a bombshell!

The tweet cuts off the title so here it is in full.

Here is the link to the PDF

So the SV40 Enhancer that Pfizer injected into billions of people without consent at 60 Billion copies per dose is a little mutation factory. It recruits a cytosine deaminase AID which is part of the APOBEC pathway.

Granted, this paper focuses on the effects of SV40 Enhancer induced mutation on SV Large Tumor Antigen (which is NOT in the Pfizer vaccine), the paper does make reference to the capacity for mutation to fall outside of SV40 T-Antigen and other viral infections can increase the rate of mutation.

While this is speculative, we must keep in mind that we shouldn’t be left to speculate what this superfluous sequence does as its not needed in the Pfizer vaccine. And Pfizer didn’t just give us an average SV40 Enhancer. They turbo charged it 5X with 2 copies.

This might explain why we see SNPs in the vaccine sequence only when its transfected into human cells. We witnessed this with OVCAR3 cell lines and with Colon Cancer Biopsies.

Is this a wrong time to remind people that Pfizer dropped $43 Billion on a cancer company called SeaGen?

Or the blood cancer company Trillium Therapeutics

This is what moving at the speed of science looks like.

Step 1) Call up your Gene Therapy Program for a few plasmids

Step 2) Obtain liability waivers and mandates for your products.

Step 3) Pay to silence dissidents on social media. Own the MSM.

Step 4) When possible pay off the NIH in form of Royalties for the vaccines. Need them to chirp on your side.

Step 5) Get former FDA heads on your BOD and on MSM.

Step 6) Hand out awards to everyone involved

Step 7) Buy Cancer companies to profit from the mess you created.

Supplement.

I asked ChatGPT about this-

What are the consequences of hypermutation in VDJ recombination due to SV40 enhancer elements and can you comment on what you would expect if people injected LNP encapsulated SV40 Promoter/Enhancer DNA fragments at 60 Billion copies per dose

ChatGPT said:

ChatGPT

VDJ recombination is the process through which B and T lymphocytes (a type of white blood cell) generate diverse antigen receptors. This process involves the random recombination of V (variable), D (diversity), and J (joining) gene segments to create a vast repertoire of antibodies and T-cell receptors. Hypermutation is a related process, specifically somatic hypermutation (SHM), which introduces point mutations in the variable regions of immunoglobulin genes, further increasing diversity after antigen exposure.

Role of SV40 Enhancer Elements

The SV40 enhancer (Simian Virus 40) is a viral DNA sequence that can increase the expression of nearby genes by acting as a transcriptional activator. Enhancer elements, like the one from SV40, are crucial in regulating gene expression by influencing promoters and transcription factors.

If SV40 enhancer elements are introduced into cells in the context of VDJ recombination:

1. Increased Expression of Immunoglobulin Genes: The SV40 enhancer could potentially boost the expression of rearranged immunoglobulin or T-cell receptor genes in lymphocytes, possibly leading to more robust receptor production. This might lead to a hyperactivation of the immune system.

2. Aberrant Somatic Hypermutation: SV40 elements could also potentially drive increased somatic hypermutation if inserted near regions involved in SHM, leading to excessive or misregulated mutation rates in the immunoglobulin genes. This can have significant consequences, such as:

   • Increased Risk of Autoimmunity: Overactivation or dysregulation of the immune response could lead to the production of self-reactive antibodies, resulting in autoimmune conditions.

   • Risk of Cancer: Increased mutation rates in lymphocytes may lead to lymphomas or other cancers if the mutations disrupt key regulatory genes that control cell division and death.

Potential Consequences of Injecting 60 Billion Copies of LNP-Encapsulated SV40 Promoter/Enhancer DNA Fragments

1. Impact of LNP Delivery: Lipid nanoparticles (LNPs) are often used for delivering genetic material (e.g., mRNA, DNA) into cells, as seen in some mRNA vaccines. When delivering SV40 promoter/enhancer DNA fragments, the consequences depend on which cells the LNPs target and whether these fragments integrate into the genome or exist as extrachromosomal elements.

   • Non-integrated DNA: If the SV40 enhancer DNA fragments do not integrate into the genome, their effects would likely be temporary, as cells typically degrade extrachromosomal DNA over time.

   • Genome Integration: If the SV40 DNA integrates into the host genome, it could dysregulate gene expression at the insertion site, potentially leading to oncogenic transformation (cancer development) or altered cellular function. The random integration of enhancers can lead to unpredictable outcomes.

2. Immune System Activation: If the SV40 enhancer fragments are taken up by immune cells, especially lymphocytes (B and T cells), they could lead to dysregulated immune responses, potentially causing:

   • Hyperstimulation of immune responses: The immune system could be overstimulated, leading to systemic inflammation or immune exhaustion.

   • Increased risk of autoimmune disorders: As the immune system becomes hyperactivated, there’s a potential risk of developing autoimmunity, where the immune system starts attacking the body’s own cells.

3. Tumorigenesis Risk: SV40 is a known oncogenic virus, and while the SV40 enhancer itself is not necessarily directly carcinogenic, its ability to drive strong gene expression could upregulate oncogenes or disrupt tumor suppressor genes, potentially increasing the risk of cancer, particularly in cells prone to high mutation rates, such as lymphocytes or other rapidly dividing cells.

4. Toxicity and Overload: 60 billion copies of DNA per dose is an enormous amount, potentially leading to toxic effects due to the overwhelming amount of foreign material. The immune system could recognize this as a massive insult, leading to severe inflammatory reactions or cytokine storm, a dangerous overreaction of the immune system.

Summary of Expectations

• Short-term effects: There may be immune activation, with the risk of systemic inflammation and immune-related adverse events.

• Long-term effects: Potential integration of SV40 enhancer elements into the genome could lead to aberrant gene expression, increasing the risk of autoimmunity or cancer.

• Toxicity risk: High doses (60 billion copies) might overwhelm the body, leading to immune system dysregulation or severe toxicity.

4o