Pfizer changed to a Tris buffer sometime in the summer of 2021. I believe its because they were having too much lipid aggregation and that was leading to lots of immediate type ADRs etc.
The EMA noted small white aggregates in their review which was waved off. Vaccinators were supposed to inspect the diluted doses and discard those with a discolouration or particulate matter. How many did that consistently? See page of the Pfizer Monograph 7-11 https://www.pfizer.ca/sites/default/files/202111/COMIRNATY_PM_EN_257698_19-Nov-2021.pdf
Oh and don't forget that Moderna had stainless steel particles large enough to be seen with the naked eye. Don't tell me they didn't know that before it left the factory. https://investors.modernatx.com/news-releases/news-release-details/ joint-statement-moderna-and-takeda-investigation-suspended-lots
As an ex hospital pharmacist we take cold chain very seriously. But most other people do not. At the beginning of the vaccine roll out there was a case of a hospital pharmacist who left boxes of Moderna out of the freezer overnight, admittedly on purpose. He is currently serving a 3 YEAR PRISON sentence for that act. Not just a fine or pulled licence. Prison. Tell me that wasn't chilling to every pharmacist who would have had some doubts about the vax. https://www.wsj.com/articles/wisconsin-pharmacist-sentenced-to-three-years-in-prison-for-tampering-with-covid-vaccines-11623186447
Regarding cold chain, if the Pfizer juice has to be kept at such a low temp to prevent agglutination, wouldn't it have to be warmed up before injecting something that cold into the body--and what does warming it up do to it? I read somewhere that it was "ok" to keep vials in the refrigerator for several days - but none of this makes any sense. I must have misunderstood.
Excellent commentary. Thank you.
I read somewhere that there were only about 200 people in the world who knew how to run these jet mixing machines at the beginning of the vaccine rollout. The machines themselves are under patent and even BioNTech or Moderna don't have access. A few were just lab bench set ups. https://blog.jonasneubert.com/2021/01/10/exploring-the-supply-chain-of-the-pfizer-biontech-and-moderna-covid-19-vaccines/
Pfizer changed to a Tris buffer sometime in the summer of 2021. I believe its because they were having too much lipid aggregation and that was leading to lots of immediate type ADRs etc.
The EMA noted small white aggregates in their review which was waved off. Vaccinators were supposed to inspect the diluted doses and discard those with a discolouration or particulate matter. How many did that consistently? See page of the Pfizer Monograph 7-11 https://www.pfizer.ca/sites/default/files/202111/COMIRNATY_PM_EN_257698_19-Nov-2021.pdf
Oh and don't forget that Moderna had stainless steel particles large enough to be seen with the naked eye. Don't tell me they didn't know that before it left the factory. https://investors.modernatx.com/news-releases/news-release-details/ joint-statement-moderna-and-takeda-investigation-suspended-lots
As an ex hospital pharmacist we take cold chain very seriously. But most other people do not. At the beginning of the vaccine roll out there was a case of a hospital pharmacist who left boxes of Moderna out of the freezer overnight, admittedly on purpose. He is currently serving a 3 YEAR PRISON sentence for that act. Not just a fine or pulled licence. Prison. Tell me that wasn't chilling to every pharmacist who would have had some doubts about the vax. https://www.wsj.com/articles/wisconsin-pharmacist-sentenced-to-three-years-in-prison-for-tampering-with-covid-vaccines-11623186447
Regarding cold chain, if the Pfizer juice has to be kept at such a low temp to prevent agglutination, wouldn't it have to be warmed up before injecting something that cold into the body--and what does warming it up do to it? I read somewhere that it was "ok" to keep vials in the refrigerator for several days - but none of this makes any sense. I must have misunderstood.
Harry. The kitten's name is Harry.
Harrison if you want to be formal.
I'm loathe to say kitty looks like a celebrity, but honestly, he kinda looks like Prince Harry :)
Don't understand it but heart it anyways.