Brilliant work, thank you for everything you are doing to expose this... It is scary to contemplate, what the implications may be for all who have had this treatment in good faith not realising just what they received...
Dr Ah Kahn Syed made an interesting observation regarding plasmid contamination on Clownbaskets substack (I'll link at bottom of this comment)
"One thing many people are missing here is (1) the quantity of CDNA/EV/plasmid is very high. It should max out at 3 per 1000 RNA (by weight) according to EMA and international standards, but this is looking to be about 1:2 so about 300 per 1000. Having that much plasmid DNA injected into you is really bad - but it gets worse.
The body can normally eradicate plasmid DNA because it's foreign and the DNAases get to work. But this is wrapped in a fluffy LNP transfectant medium, so will get to every cell that the LNP touches. It will transfect the nucleus of those cells, no problem.
So now you have active EV/plasmid DNA in a LNP available to either produce huge quantities of RNA (because that's what they are there for) or else integrate into the genome - which will happen during cell division even in the absence of a specific integrase enzyme.
The quantity available is the deal breaker because it is now present in the same magnitude of amount as the RNA. They might as well have injected the self-amplifying RNA version that they wanted to from the beginning."
My take (I only have rudimentary memory from studying biology, poorly, at uni in the 90s).... The LNP... bypasses normal bodily processes of recognition and destruction, and deliver straight into cytoplasm...(and then nucleus) cellular mitosis either doubling amount due to cytoplasmic capture (and replication ability of circular plasmids), or contained within nucleus, in which case mitosis transcription error then cancer or autoimmune problems, not to mention systemic interference in normal cellular processes... I hope I read this right?? (or maybe I hope I haven't read this right, I'm praying that I have it wrong here, as this could be a bigger disaster than we've already seen worldwide).
Thank you once again for all your hard work and dedication, a million thank you's is not enough...
Is there evidence that the LNPs transfect the nucleus? I wouldn't doubt it, but as I understand it they're SUPPOSED to fuse with the phospholipid bilayer. I would be interested in seeing research showing nuclear transfection via LNPs, or at least that the genetic material absolutely gets into the nucleus, no LNP needed
"So now you have active EV/plasmid DNA in a LNP available to either produce huge quantities of RNA"
There are a lot of things concerning the codon optimization that already had me suspicious the RNA may not degrade at the rate it normally would, guanine enrichment and m1ψ just to start with. The replication count was already rather high, without degradation issues or plasmids that might pump out additional RNA copies. Lots of details can be found in here concerning the optimization.
A vital point: they state in the paper that the RNA may be vulnerable to zinc finger antiviral proteins. However since replication was apparently the only goal, seems muscle cells are rather lacking in ZAP. Something they don't mention, but is apparent in their tables, is that it is also rather low in many internal organs, and also very low (if I remember right) in endothelial tissue or heart tissue, I can't remember which. If the RNA is truly degradable by ZAP, perhaps the table distributions would help determine which organs are most at risk (if combined with biodistribution data). I know it doesn't help much for the current plasmid issue, but it's a thought that may help regardless
I know we don't get along well Kevin, but I want to state you are a officially a hero in my book for this, no matter how insufferable we may find each other to be. I'm glad someone finally found viable reproducible evidence. Thank you.
I'd not doubt it (I was quoting Dr Ah Kahn Syed) certainly into the cytoplasm, but foreign DNA plasmids can be taken up by the nuclear DNA, as this particular substack shows...
Do those plasmid DNA fragments generate bacterial/viral peptides that will attract immunity or activate T killer cells? (Are they immunogenic?) What will happen if they are integrated into the genome of cells? Will those cells get killed off?
If they're the copies of plasmids the mRNA is produced from, and can still be read somehow inside a eukaryotic cell, I would imagine they would create additional copies of spike creating mRNA (this is all very hypothetical). Think of a book that can be copied an unknown amount of times. For that to happen they would have be transcripted by an RNA polymerase, how many times I have no idea, or if it's even possible, but that process is where you should start looking for answers. If they are integrated I think it again, depends. There's the possibility for disease through addition of genes which should not be present, or, conversely, they may deleted/suppress important genes when they are integrated. As for those cells being killed off.... Again I have no idea. Theoretically if they push out spike protein they should be identified and eliminated by T cells, but.... I'm not so sure, as spike presence in individuals for so long past when it should be there makes this thought seem counterintuitive, or that at least something is going wrong. Maybe not all cells are being eliminated, and the plasmids are the best reason why those cells can still produce spike? I only say this because I saw a slide of a woman's lung tissue (alive, transfected) who was still producing spike something like 6 months out, but don't quote me on that. I would say worst case, would be they stop producing spike before they are identified and eliminated, and then integration occurs, causing disease through deletion/suppression, which might be more stealthy than if the integration causes the cell to push out a peptide it shouldn't be. Again though, all incredibly hypothetical
I am talking about if the plasmid themselves are immunogenic to the body since they are the organelles directly come from the bacteria, not the spikes the mRNA produces.
I am also not sure of how human bodies respond to plasmids. Unless the LNPs are aggregated though, the mRNA and DNA should be housed in lipids. They should transfect cells at least into the cytoplasm, which is why I only gave you information about what happens in the cell. The DNA can't be immunogenic unless the immune system can see it, which it likely won't if it's disguised as an exosome like particle. However, they may be immunogenic inside the cell for all I know. Cell biology is incredibly complicated after all. The mRNA codon optimization was done to make the mRNA itself look more "human" so, perhaps, indeed there would be a larger issue if a plasmid was floating around, as surely it's not completely codon optimized around the entire plasmid? Again, postulating. Very difficult topic. People like Kevin are likely the only ones knowledgeable enough to answer your question well (well researched genius geneticists/immunologists that aren't bought)
Awesome sauce, sorry I hadn't been through your links yet.
Edit: scratch that, I've read this one. I'm more concerned if we can show the DNA plasmids get to the nucleus. I'm aware the Plasmids may be taken up the nuclear DNA, but they would have to get into the nucleus first. I know the spike can get in there, which may be a result of the nuclear localization sequence, but I'm not sure of evidence the mRNA gets there, or that the LNPs transfect the nucleus. I don't doubt ark medic but we need step by step proof, or the dan wilsons of the world will just say "yeah but it's cool you have plasmids in your cytoplasm because they can't enter your nucleus"
An equally important point might be the mito. The mito also has circular DNA, and is certainly before the nucleus, there in the cytosol. This is where my knowledge of internal cell biology is not strong enough to postulate further unfortunately
Mine too (biology at uni was a few decades ago for me)... I'll see what can be dug up... As nanolipidparticle delivery systems should as you say be left around/fused with the cell membrane or perhaps cytoplasm, one would think the payload delivery would stop there... Might be worth postulating to Arkmedic, he may have access to recent data...
"We further found that DOTAP/chol LNPs were able to transfect pDNA and oligonucleotides, demonstrating the ability of these LNPs to transport the cargo into the cell nucleus."
Do those plasmid DNA fragments generate bacterial/viral peptides that will attract immunity or activate T killer cells? (Are they immunogenic?) What will happen if they are integrated into the genome of cells? Will those cells get killed off?
I watched the CHD TV interview with Jessica. Unfortunately the sound was quite poor and I’m sure that will prevent this very important message from gaining coverage. Is there any chance you could repeat it? Thank you for everything you are doing.
Since the discussion in comments covers lots of history of Weaponization, can anyone explain the renaming of Mason-Pfizer Monkey Virus (M-PMV), formerly Simian RetroVirus (SRV) ? Appears to go back at least to 1986.
That's what gets me. They had to know that someone would get ahold of some vials. They couldn't hide everything forever. But then, maybe they don't have to. Enough people have already been jabbed to cause a serious global impact.
The question is, what is going to happen to those who were jabbed, a few years down the road?
I climbed to the top of the Duomo, out of shape and wheezing, but did it to race with my teenagers. If you ever get the chance do it. It's one of the most exciting amazing interactions with art and architecture you will ever experience!
Keep climbing the mountain of evidence showing the contamination in the shots Kevin.
Thanks very much for that, I had seen the DoE was in control of US Bioweapons research and was funding GMO Coronavirus in Spain in 2000 or before. Do you have information on the first date of Furin insertion?
This doesn't quite answer the question you posted above Geoff, but thinking of the international collaboration to this whole disaster/sham, I couldn't find an article to nail it down but apparently CSIRO, or equivalent helped with the HIV inserts in previous spike protein assemblies... Closest to that info I could find is mentioned at 18 seconds into this video
I'm assuming there's a lot of (perhaps unknowingly assisting) collaborative development, internationally, over a long period of time, Igor Chudov's latest post also shows a timeline of development that may have led to the construction of this spike protein .
Such as....
*In this 2008 grant, Amy Sims, who worked with Ralph Baric at UNC, describes her idea to put bits of Simian Immunodeficiency Virus (SIV, a precursor of HIV) into a human common cold virus OC43."
Brilliant work, thank you for everything you are doing to expose this... It is scary to contemplate, what the implications may be for all who have had this treatment in good faith not realising just what they received...
Dr Ah Kahn Syed made an interesting observation regarding plasmid contamination on Clownbaskets substack (I'll link at bottom of this comment)
"One thing many people are missing here is (1) the quantity of CDNA/EV/plasmid is very high. It should max out at 3 per 1000 RNA (by weight) according to EMA and international standards, but this is looking to be about 1:2 so about 300 per 1000. Having that much plasmid DNA injected into you is really bad - but it gets worse.
The body can normally eradicate plasmid DNA because it's foreign and the DNAases get to work. But this is wrapped in a fluffy LNP transfectant medium, so will get to every cell that the LNP touches. It will transfect the nucleus of those cells, no problem.
So now you have active EV/plasmid DNA in a LNP available to either produce huge quantities of RNA (because that's what they are there for) or else integrate into the genome - which will happen during cell division even in the absence of a specific integrase enzyme.
The quantity available is the deal breaker because it is now present in the same magnitude of amount as the RNA. They might as well have injected the self-amplifying RNA version that they wanted to from the beginning."
My take (I only have rudimentary memory from studying biology, poorly, at uni in the 90s).... The LNP... bypasses normal bodily processes of recognition and destruction, and deliver straight into cytoplasm...(and then nucleus) cellular mitosis either doubling amount due to cytoplasmic capture (and replication ability of circular plasmids), or contained within nucleus, in which case mitosis transcription error then cancer or autoimmune problems, not to mention systemic interference in normal cellular processes... I hope I read this right?? (or maybe I hope I haven't read this right, I'm praying that I have it wrong here, as this could be a bigger disaster than we've already seen worldwide).
Thank you once again for all your hard work and dedication, a million thank you's is not enough...
Links to mentioned article and comments
https://clownbasket.substack.com/p/explainer-expression-vector-contamination
https://clownbasket.substack.com/p/explainer-expression-vector-contamination/comment/13629457?utm_source=share&utm_medium=android
Is there evidence that the LNPs transfect the nucleus? I wouldn't doubt it, but as I understand it they're SUPPOSED to fuse with the phospholipid bilayer. I would be interested in seeing research showing nuclear transfection via LNPs, or at least that the genetic material absolutely gets into the nucleus, no LNP needed
Also this part.
"So now you have active EV/plasmid DNA in a LNP available to either produce huge quantities of RNA"
There are a lot of things concerning the codon optimization that already had me suspicious the RNA may not degrade at the rate it normally would, guanine enrichment and m1ψ just to start with. The replication count was already rather high, without degradation issues or plasmids that might pump out additional RNA copies. Lots of details can be found in here concerning the optimization.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310186/pdf/vaccines-09-00734.pdf
A vital point: they state in the paper that the RNA may be vulnerable to zinc finger antiviral proteins. However since replication was apparently the only goal, seems muscle cells are rather lacking in ZAP. Something they don't mention, but is apparent in their tables, is that it is also rather low in many internal organs, and also very low (if I remember right) in endothelial tissue or heart tissue, I can't remember which. If the RNA is truly degradable by ZAP, perhaps the table distributions would help determine which organs are most at risk (if combined with biodistribution data). I know it doesn't help much for the current plasmid issue, but it's a thought that may help regardless
I know we don't get along well Kevin, but I want to state you are a officially a hero in my book for this, no matter how insufferable we may find each other to be. I'm glad someone finally found viable reproducible evidence. Thank you.
I'd not doubt it (I was quoting Dr Ah Kahn Syed) certainly into the cytoplasm, but foreign DNA plasmids can be taken up by the nuclear DNA, as this particular substack shows...
https://clownbasket.substack.com/p/explainer-expression-vector-contamination
Do those plasmid DNA fragments generate bacterial/viral peptides that will attract immunity or activate T killer cells? (Are they immunogenic?) What will happen if they are integrated into the genome of cells? Will those cells get killed off?
If they're the copies of plasmids the mRNA is produced from, and can still be read somehow inside a eukaryotic cell, I would imagine they would create additional copies of spike creating mRNA (this is all very hypothetical). Think of a book that can be copied an unknown amount of times. For that to happen they would have be transcripted by an RNA polymerase, how many times I have no idea, or if it's even possible, but that process is where you should start looking for answers. If they are integrated I think it again, depends. There's the possibility for disease through addition of genes which should not be present, or, conversely, they may deleted/suppress important genes when they are integrated. As for those cells being killed off.... Again I have no idea. Theoretically if they push out spike protein they should be identified and eliminated by T cells, but.... I'm not so sure, as spike presence in individuals for so long past when it should be there makes this thought seem counterintuitive, or that at least something is going wrong. Maybe not all cells are being eliminated, and the plasmids are the best reason why those cells can still produce spike? I only say this because I saw a slide of a woman's lung tissue (alive, transfected) who was still producing spike something like 6 months out, but don't quote me on that. I would say worst case, would be they stop producing spike before they are identified and eliminated, and then integration occurs, causing disease through deletion/suppression, which might be more stealthy than if the integration causes the cell to push out a peptide it shouldn't be. Again though, all incredibly hypothetical
I am talking about if the plasmid themselves are immunogenic to the body since they are the organelles directly come from the bacteria, not the spikes the mRNA produces.
I am also not sure of how human bodies respond to plasmids. Unless the LNPs are aggregated though, the mRNA and DNA should be housed in lipids. They should transfect cells at least into the cytoplasm, which is why I only gave you information about what happens in the cell. The DNA can't be immunogenic unless the immune system can see it, which it likely won't if it's disguised as an exosome like particle. However, they may be immunogenic inside the cell for all I know. Cell biology is incredibly complicated after all. The mRNA codon optimization was done to make the mRNA itself look more "human" so, perhaps, indeed there would be a larger issue if a plasmid was floating around, as surely it's not completely codon optimized around the entire plasmid? Again, postulating. Very difficult topic. People like Kevin are likely the only ones knowledgeable enough to answer your question well (well researched genius geneticists/immunologists that aren't bought)
Awesome sauce, sorry I hadn't been through your links yet.
Edit: scratch that, I've read this one. I'm more concerned if we can show the DNA plasmids get to the nucleus. I'm aware the Plasmids may be taken up the nuclear DNA, but they would have to get into the nucleus first. I know the spike can get in there, which may be a result of the nuclear localization sequence, but I'm not sure of evidence the mRNA gets there, or that the LNPs transfect the nucleus. I don't doubt ark medic but we need step by step proof, or the dan wilsons of the world will just say "yeah but it's cool you have plasmids in your cytoplasm because they can't enter your nucleus"
An equally important point might be the mito. The mito also has circular DNA, and is certainly before the nucleus, there in the cytosol. This is where my knowledge of internal cell biology is not strong enough to postulate further unfortunately
Mine too (biology at uni was a few decades ago for me)... I'll see what can be dug up... As nanolipidparticle delivery systems should as you say be left around/fused with the cell membrane or perhaps cytoplasm, one would think the payload delivery would stop there... Might be worth postulating to Arkmedic, he may have access to recent data...
I'll bounce over there and inquire tomorrow, appreciate the advice
What about this one?
"We further found that DOTAP/chol LNPs were able to transfect pDNA and oligonucleotides, demonstrating the ability of these LNPs to transport the cargo into the cell nucleus."
https://pubmed.ncbi.nlm.nih.gov/35534697/
Check with Dr Ah Kahn Syed maybe, but it seems to be what he's talking about?
you should have studied longer , wayyyyyy longer !!!
Do those plasmid DNA fragments generate bacterial/viral peptides that will attract immunity or activate T killer cells? (Are they immunogenic?) What will happen if they are integrated into the genome of cells? Will those cells get killed off?
Good work - should set off the fire alarms - well done. Hope you can re-run this with some fresher samples, too.
Kevin thank you for this work. I hope it goes down in history.
I watched the CHD TV interview with Jessica. Unfortunately the sound was quite poor and I’m sure that will prevent this very important message from gaining coverage. Is there any chance you could repeat it? Thank you for everything you are doing.
Hiding the blueprints is only less successful in light of the brilliant research of Kevin McKernan and others. Thank you!
P.S. Perhaps some more diversionary "squid ink", as you have termed it, is necessary.
Since the discussion in comments covers lots of history of Weaponization, can anyone explain the renaming of Mason-Pfizer Monkey Virus (M-PMV), formerly Simian RetroVirus (SRV) ? Appears to go back at least to 1986.
I would like to have the training to competently evaluate this paper but I do not.
Can't do everything :)
Excellent work again! Now this need to repeated by every state and country around the world for evidence in criminal trials.
That's what gets me. They had to know that someone would get ahold of some vials. They couldn't hide everything forever. But then, maybe they don't have to. Enough people have already been jabbed to cause a serious global impact.
The question is, what is going to happen to those who were jabbed, a few years down the road?
This Pfizer vial of Lot FL8095 contains Sugar and Tromethamine.
Is there any evidence they might interfere with your Reverse Transcriptase?
https://geoffpain.substack.com/p/tromethamine-is-a-hazardous-substance
I climbed to the top of the Duomo, out of shape and wheezing, but did it to race with my teenagers. If you ever get the chance do it. It's one of the most exciting amazing interactions with art and architecture you will ever experience!
Keep climbing the mountain of evidence showing the contamination in the shots Kevin.
https://www.visitflorence.com/florence-churches/climbing-to-the-top-of-duomo.html
Thanks very much for that, I had seen the DoE was in control of US Bioweapons research and was funding GMO Coronavirus in Spain in 2000 or before. Do you have information on the first date of Furin insertion?
This doesn't quite answer the question you posted above Geoff, but thinking of the international collaboration to this whole disaster/sham, I couldn't find an article to nail it down but apparently CSIRO, or equivalent helped with the HIV inserts in previous spike protein assemblies... Closest to that info I could find is mentioned at 18 seconds into this video
https://www.bitchute.com/video/IZDpra7vJB4E/
I'm assuming there's a lot of (perhaps unknowingly assisting) collaborative development, internationally, over a long period of time, Igor Chudov's latest post also shows a timeline of development that may have led to the construction of this spike protein .
Such as....
*In this 2008 grant, Amy Sims, who worked with Ralph Baric at UNC, describes her idea to put bits of Simian Immunodeficiency Virus (SIV, a precursor of HIV) into a human common cold virus OC43."
Source https://igorchudov.substack.com/p/ralph-barics-description-of-the-perfect?token=eyJ1c2VyX2lkIjo1MDMyNDA4MSwicG9zdF9pZCI6MTEwNjM4NTk3LCJpYXQiOjE2Nzk3OTQwMDgsImV4cCI6MTY4MjM4NjAwOCwiaXNzIjoicHViLTQ0MTE4NSIsInN1YiI6InBvc3QtcmVhY3Rpb24ifQ.UZF0T-VfkqtP8IMhkNjXDJtmicBh4QDfsN_WnUKp_Eo
Sorry bit off target, but might help expand upon what you're seeking (fingers crossed)
Wow, thanks for that reference, and yes I can definitely see this...
I look forward to reading the link...
Thanks very much. Furin is king of weaponization.
Very interesting thanks. I have been to Baku, Azerbaijan but not Turkey - cradle of BioNTech
Thanks very much. Will add Baltimore and Brazil to deep diving list.
Yes replication competent viruses are routinely made in labs in US and elsewhere using the plasmid assembly technique.
As sergeant Schultz says re chromosome jumping - I Know Nothing
But I see a lot, hear a lot.