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RexesRule's avatar

Seems that every aspect of the The Science™ is totally corrupted by industry money, and run by a cabal of low integrity "experts" who eagerly race through the revolving door to a cushy pharma gig.

When government science agencies base decisions on who's given them the most money, that's not science, that's an auction.

RexesRule's avatar

Amount of Money Involved

Lobbying spending by the pharmaceuticals/health products industry reached $341,316,466 in 2025 (through Q3), on pace to exceed the 2024 record of $385-388 million.

PhRMA alone spent $37.9-38 million, its highest ever, up 22% from 2024.

Top spenders include:PhRMA: $37.9M

Pfizer: $8.86M

Merck: $9.19M

Eli Lilly: $8.43M

Novartis: $6.22M

Bristol-Myers Squibb: $5.28M (91% increase from 2024)

From 1998-2025, the industry spent over $6.36 billion on lobbying.

Additional funds flow through donations, such as $6.5M to Trump's inauguration from PhRMA and members.

https://x.com/i/grok?conversation=2016933426788749582

edward's avatar

And so it has always been..."Love of money is the root of all evil." And will ever be to the end.

Crixcyon's avatar

All they are ever boosting is the amount of toxic poisons in your body.

Jayne Doe's avatar

Results from your question using google search ai - +9 The presence of bacterial methylation signals (DAM/DCM), RNA:DNA hybrids, and methylated RNA in contaminants triggers a complex and often confusing immune response because these elements mimic pathogen-associated molecular patterns (PAMPs), leading to unintended activation of innate immunity.

Bacterial Methylation Signals (Dam/Dcm): These signals (N6-methyladenine from Dam, C5-methylcytosine from Dcm) are typical of prokaryotic DNA. When present in contaminants, they are recognized as foreign by mammalian receptors. Such patterns can trigger immune responses, including inflammation or, if they act as adjuvants, potentially confuse the adaptive immune system by creating a mixed signal.

RNA:DNA Hybrids: These structures are recognized by the innate immune system as foreign, often signaling viral infection or DNA damage. Studies show that RNA:DNA hybrids are sensed by pattern recognition receptors (PRRs) like TLR9, triggering the production of pro-inflammatory cytokines and Type I interferon. They are considered a novel, potent molecular pattern for inducing inflammation.

Methylated RNA: Methylation modifications (e.g., m6A, m5C) on RNA are key regulators of immune cell function. Methylated RNA can interfere with host immune responses and contribute to the "confusion" of the immune system by acting as a signal that may either be interpreted as self or foreign depending on the context.

Immune Confusion/Dysregulation: The combination of these bacterial and modified signals can lead to a "confusing" response because the body may mistake these contaminants for an active, multi-layered infection, leading to chronic inflammation, immune evasion, or autoimmune-like reactivity.

In essence, these contaminants mimic a complex, ongoing infection, inducing a robust innate response that is difficult for the host to resolve.

Janice's avatar

There was excitement some years back about overmethylation and undermethylation as conditions causing dysfunctions in some humans (see William Walsh). SAMe (S-Adenosyl-L-Methionine ) was one of the supplements prescribed as remedies.

My interest extends to any informed thoughts expressed by humans (misspell something, LOL !), but not by any AI .

Marty Ellenbecker's avatar

That's cool!

Now try to get google search ai to vindicate Ivermectin.

Patte Kelly's avatar

Can Ecoli bacteria be placed/incorporated in toilet paper so as to infect the female with a UTI. Many strains of Ecoli, are becoming resistant to antibiotics. That is causing an on going problem. Gives Pharma more monies and women more problems. While at a hospital lab I noticed a lot of " caps " in the trash container . Inquired about all of them , wondering if that was " NORMAL " ! Answered...YES ! A YOU TUBE commercial I had seen Twice showed a mother sitting On a public toilet, nursing a baby...She stated " They are infecting you using ....TOILET PAPER." Only saw twice. Is it POSSIBLE this could be happening ? A whistle Blower . We love ....WHISTLE BLOWERS . Need a TON MORE !

Rich's avatar

Amazing Jessica, AI will not be able to come within light years of your deep wisdom.

When you focus your light on a subject the view is astounding.

Thank you.

Patte Kelly's avatar

Proud of YOU ! ! ! Would Not Be " PROUDER " if YOU were my Own Daughter ! ! !

Jan's avatar

Exactly … I firmly believe Jessica is a gift sent to us from God to help humanity with her brilliance beyond any AI, to help humanity gracefully and gently after being made so sick from these wretched vaccines … whom some of us had no choice but to take it.

I believe she’ll with her beautiful sense of humor and compassion for us all … we’re with the right person and can 100% believe her. Thank you Jessica. I puddle through since beginning, best I can.

Jan 💝

Brandon is not your bro's avatar

And Dr. Kevin 💥too.🤗

norica's avatar

I would not be surprised if the next "outbreak" was designed to take advantage of very specific immunodeficiencies that this therapy induced.

tomasz's avatar

"The nature of the contaminants also presents a very confusing immune response as they contain bacterial methylation signals (DAM/DCM), RNA:DNA hybrids and methylated RNA."

By design or by accident?

Jen's avatar

As an immunologist, I believe vaccine developers are misguided. More is not better in immunology. In fact more stimulation by antigens + antigens causes a homeostatic correction that causes immune suppression.

Castigator's avatar

But freemasons are delighted with the results! The more, the merrier depopulation-wise.

Neural Foundry's avatar

Fascinating angle on the DAM/DCM methylation signals combined with RNA:DNA hybrids! The triple confusion concept explains why we're seeing such paradoxical immune responses. I dunno if most clinicians grasp how bacterial vs eukaryotic methylation patterns trigger totally diffrent pathways. Your Claude.ai experiment is telling, these contaminant combos create a biochemical mess nobody properly modeled befor deployment.

Creator's avatar

Of course there was data to suggest rapid boosting might help - convincing results of not only 8, but over all 16 mice! Our glorious fact checkers did a really great job exposing this: correctiv.org/faktencheck/2022/09/08/nur-an-acht-maeusen-getestet-behauptungen-ueber-omikron-booster-impfstoffe-fuehren-in-die-irre/

BadProtein's avatar

Gemini says Spike is soooooooo last year! FUGGET ABOUT IT. History Rewrites Itself!

Looks like the Japanese have passed the first round - UK has just approved self-amplifying according to Gemini.

I was talking to Gemini about an old Omicron paper where the authors declared targeting spike was now (then) useless...

>>>>so they were ignored

It might seem that way from a distance, but the scientific and medical community actually underwent a massive, rapid shift in line with what Saxena and others were warning. They didn’t ignore the advice—they were essentially forced into it by the virus’s evolution.

Here is the "on-the-ground" reality of how that course change played out between 2022 and today:

1. The "Death" of Monoclonal Antibodies

Attachment inhibitors (specifically Monoclonal Antibodies) were the primary defense during the Delta wave. But as Saxena predicted, Omicron rendered them nearly useless.

The Wipeout: One by one, the FDA had to revoke the emergency use authorizations (EUAs) for famous treatments like Regeneron and Sotrovimab. Why? Because they targeted the Spike protein, and Omicron’s Spike protein had changed so much the drugs could no longer "grab" it.

The Result: By early 2023, there were almost no monoclonal antibodies left that worked against the circulating Omicron sub-variants. The strategy of "blocking the attachment" hit a brick wall.

2. The Rise of the "Engine Blockers"

Because attachment was no longer a reliable target, medicine shifted to the "internal" targets the paper recommended.

Paxlovid (Nirmatrelvir/Ritonavir): This became the gold standard. Instead of blocking the Spike protein (attachment), it blocks the Protease (the virus's "scissors"). Because the protease doesn't mutate as fast as the Spike, Paxlovid remained effective through BA.1, BA.5, XBB, and the current 2026 variants.

Molnupiravir: Similarly, this drug targets the virus's "copy machine" (Polymerase). Even as the Spike protein "disguised" itself, the copy machine stayed the same, making this drug a durable backup.

3. Why it might feel like they were ignored

If it feels like the warnings were "ignored," it’s likely because of Vaccines.

The "Spike-Centric" Vaccine Loop: Our main vaccines (Pfizer, Moderna) still focus on the Spike protein. Scientists haven't "ignored" the need for change, but creating a "universal" vaccine that targets the internal parts of the virus is much harder than creating a Spike-based one.

Updating vs. Changing: Instead of a full "course change" for vaccines, we have stayed in a cycle of "updating the software"—releasing new boosters (like the XBB or JN.1 versions) that match the latest Spike protein.

Summary: Who listened?

Drug Manufacturers: Listened. They pivoted to Protease and Polymerase inhibitors (like Paxlovid) which are now our primary treatments.

Regulators (FDA/WHO): Listened. They moved very quickly to pull ineffective attachment inhibitors off the market once the data showed Omicron was evading them.

Vaccine Makers: Compromised. They are still using the "Spike" method but are stuck in an annual update cycle, similar to the flu shot.

The "course change" Saxena suggested effectively became the standard for how we treat COVID-19 in a clinic today. Are you interested in how the newest "universal" vaccines—the ones that try to avoid the Spike protein entirely—are coming along in 2026?

>>>>>>>>>>>>let's see the future

In early 2026, the "future" the authors envisioned is now our current reality. The scientific community has largely accepted that chasing the Spike protein is like playing a game of Whac-A-Mole, and we are seeing a massive shift toward "Variant-Proof" and "Pancoronavirus" strategies.

Here is the 2026 outlook on that "course change":

1. The "Universal" Vaccine Milestone

Just this month (January 2026), SK bioscience initiated a global Phase 1/2 clinical trial for GBP511, a vaccine designed to target the entire Sarbecovirus family (the group that includes SARS, SARS-CoV-2, and potential future animal-to-human spillover viruses).

The Strategy: Instead of just the Spike, it uses a nanoparticle platform to present "conserved" parts of the virus that don't change between variants.

The Goal: To create a vaccine that doesn't need to be updated every year, finally breaking the "Spike-chasing" cycle.

2. Targeting the "Internal" Machinery

The advice from Saxena et al. to move away from attachment inhibitors has resulted in a new generation of vaccines that look inside the virus:

Nucleocapsid (N) Protein Vaccines: Since the N-protein is much more stable than the Spike, several "next-gen" candidates (like the Convacell platform) are focusing on it to provide broad T-cell immunity. This ensures that even if the virus "disguises" its exterior (Spike), your body still recognizes its internal "skeleton."

Self-Amplifying mRNA (samRNA): A newer version of mRNA technology (Kostaive/Zapomeran) has just been authorized in the UK (January 2026). It stays in the body longer and produces a more robust, durable response than the original 2021-era mRNA shots.

3. Blocking the Entryway: Mucosal Vaccines

A major focus in 2026 is stopping the virus before it can even attach to the lungs.

Nasal Sprays: At least 36 mucosal vaccines have reached clinical trials. The data now shows that nasal vaccines are superior at limiting viral replication in the upper airways, which could finally halt transmission—something the injectable "Spike-only" vaccines struggled to do.

Finnish & US Trials: New Phase 1 and 2 trials for nasal vector vaccines (like those from Rokote and Castlevax) are currently recruiting, aiming to create a "wall of immunity" in the nose.

4. Treatment Pivot: Beyond Antivirals

For those who do get sick, the focus has shifted toward preventing Long COVID by targeting inflammation at its source:

Metformin: Recent 2025/2026 data confirms it can reduce Long COVID risk by up to 41% if taken early.

Immune Modulators: We are seeing a move toward drugs that target JAK and mTOR pathways to stop the "cytokine storm" before it starts, rather than just trying to block viral attachment.

Summary of the 2026 Course Change

Old Strategy (2021-2023) New Strategy (2026)

Spike-Targeting Antibodies Broad Protease/Polymerase Inhibitors

Injectable mRNA (Systemic) Intranasal/Mucosal (Localized)

Variant-Specific Boosters Pancoronavirus / Universal Candidates

Attachment Inhibition T-Cell / Conserved Protein Protection

The "course change" suggested in that paper was not ignored; it became the blueprint for pandemic phase 2. We've stopped trying to build a better "lock" and started trying to disable the "engine" of the virus itself.

Would you like to look closer at one of these 2026 clinical trials, or perhaps see how the latest nasal vaccines are performing in real-world data?

edward's avatar

Dr J has more than an abiding ability to correlate and comprehend what is Dutch to me. As in every woman she has a lot of little girl in her noted by the little things she does. In that capacity I wonder if anyone else has seen her in an interview or at the beginning of one when she grabs a handful of her hair, twists and manoeuvres it on the top/back of her head, and establishes it in the proper location just before she gets into the "whats what" in the conversation/topic she is addressing. Having seen her do that trick I wonder if it would be easier or harder than following her in her myriad of explanations on a given subject as the expert she is.

I am thinking she will wonder why and how I noticed that. I am sure others has as well. The reality is that grown women exhibit that "cuteness" which I noted long ago in high school that makes that little girl part of them manifest. And believe me, it is sooooo cute.

If you are a male and do not note that then you are missing what to me is one of the intricacies of the fairer gender.

I need to shortly focus on Celia with the pretty name as well. These two are anomalies to me but as with all women, they are all the same but always different. And that is one of the things that makes them so sublime from the tips of their pretty heads to the tip of their toes.

Others have wondered if there is a perfect woman in my estimation. No, they are all perfect. But I will confess there is one who is a very close friend and has been since 2004...that is over two decades. And others as well in my life but THAT one whose hurt I stole ended up with stealing her heart. Yet in principle that one has been perfect in conduct, friendship and cameraderie. Yes there are others BUT she was and is the first one whose hurt and pain she confided in me about and the first time I was ever broken. And that in front of her.

The women here are largely conservative and due to that they are sensible, logical and intellectually superior to most other women. So here is to woman. Would that we could fall into her arms without falling into her hands. (Ambrose Pierce)

Yes I realize that screaming banshees masquerading as women could attack me for daring to tell the Truth and being transparent. I dare say that those in my life adore me for one reason. It is my transparency they love. They are all aware that whatever is in my head will eventually pass between my lips whether it gets me in trouble or not. And that is the truth.

Marty Ellenbecker's avatar

When the US Government finally took HIV/AIDS seriously, [1992]

they sent -to every US household- a What-to-not-to-how-to-brochure

about the disease.

𝗧𝗵𝗶𝘀 𝗻𝗲𝘄 𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗼𝗻 𝗶𝘀 𝗲𝗾𝘂𝗮𝗹𝗹𝘆 𝘂𝗿𝗴𝗲𝗻𝘁, 𝗮𝗻𝗱 𝗻𝗲𝗲𝗱𝘀 𝘁𝗼 𝗯𝗲 𝘀𝗲𝗻𝘁 - 𝗯𝘆 𝗿𝗲𝗴𝗶𝘀𝘁𝗲𝗿𝗲𝗱 𝗺𝗮𝗶𝗹 - 𝘁𝗼 every practitioner, provider, advisor, educator, student, laboratory

𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗲𝗹𝗱𝘀 𝗼𝗳 -

Immunology, Pediatrics, Maternity, Pharmacology,

[Patients would receive it directly and sign a receipt for it]

𝗜𝘁 𝘀𝗵𝗼𝘂𝗹𝗱 𝗮𝗽𝗽𝗲𝗮𝗿 𝗶𝗻 𝗮𝗹𝗹 𝗿𝗲𝗹𝗲𝘃𝗮𝗻𝘁 𝗲𝘅𝗮𝗺𝘀/𝗱𝗼𝗰𝘂𝗺𝗲𝗻𝘁𝘀 𝗳𝗼𝗿

entrance, certification, recertification to provide services, products,

information or advice in the aforementioned fields.

(This would also help RFK Jr "Tighten up the ship".)