Patent tour and freezer clean out

Our freezers are full. In attempt to clean house I have noticed a few other vax related material sent to us that the team needs to dispose of.

Before they are disposed of, I threw them through their final qPCR. FL0007 was fully consumed making an Oxford Nanopore library. That sequencing has already been described here.

The Comirnaty vials from Japan were ~10 fold lower in dsDNA contamination than Pfizer monovalent FL0007, reminding us of the lot to lot heterogeneity of these products.

Moderna XBB 12 and older preloaded shots. These are some of the lowest CT scores I’ve seen from Moderna (CT under 20 on Spike). Still better than Pfizer but the problem isn’t getting better. It’s getting worse.

Below are the Moderna CT scores from Dr. David Speichers Moderna samples. Most samples are 3+ CTs later for Spike (23-24).

To bring some context to the dsDNA contamination its important to see a few patents that have the CEO of Moderna as an inventor.

Interesting points raised by Patent_SUN

So the manufacturers have filed patents on the methods they are using to remove dsDNA as they know this creates a risk of insertional mutagenesis. They are on record with the USPTO back in 2018 bragging about the benefits of mRNA as they don’t cary the dsDNA risks of other vaccine approaches!

In theory, they carry less risk than a pure DNA vaccine. This is likely true but should be tested in genotoxicity studies as the fragmentation of the DNA and the inclusion of Nuclear targeting sequencing could radically alter this false equivalence.

The manufacturers are also on record stating that qPCR underestimates the dsDNA contamination, yet it is used in their testing with regulators.

Of note Moderna’s own patent, which includes their CEO as an inventor, relies on using 2 different nucleases which may explain why their DNA content is lower than Pfizers.

This may have something to do with the FDA’s denialism.

Zerohedge hasn’t let up on this.

My latest interview on the topic with Dr. Craig Wax.